New PDF release: Clinical Trials in Psychiatry

By Brian S. Everitt, Simon Wessely

ISBN-10: 0198526423

ISBN-13: 9780198526421

Psychological illnesses account for 1 / 4 of all healthcare professional consultations, and position a big monetary burden on society. hence, the quest for potent remedies in psychiatry keeps apace. yet as they're constructed, it's crucial that we've got powerful and rigorous tools of assessing the advantages and safeguard of latest remedies. The randomised managed trial (RCT) is authorized as being the easiest approach for doing this. so as to comprehend what does and doesn't paintings, psychological well-being pros have to know how remedies were assessed and evaluated. scientific Trials in Psychiatry is the 1st ebook to provide an explanation for RCTs for psychological healthiness execs. It starts off via discussing why we'd like trials and why they're the way in which of finding out if a therapy works. It then describes the different sorts of trials, tips to examine the implications, and the way to behavior a tribulation. For somebody operating within the psychological healthiness box, this e-book could be an important resource of reference, letting them make proficient judgements approximately remedy.

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CTIPC02 13/9/03 11:45 AM Page 25 THE RANDOMIZED CLINICAL TRIAL This book will be largely concerned with phase III trials. ) and are known as multicentre trials. The principal advantage of carrying out a multicentre trial is that patient accrual is much quicker so that the trial can be made larger and the planned number of patients can be achieved more quickly. The end-result should be that a multicentre trial reaches more reliable conclusions at a faster rate, so that overall progress in the treatment of a given disease is enhanced.

The available data suggest that you will live an average of five months longer on A than on B. But there is substantial variability in the data, and many people who have received B have lived longer than some patients on A. If I were you I would prefer A. My probability that you live longer on A is 25 per cent. Your participation in this trial will help us treat other patients with this disease, so I ask you in their name. But if you choose not to participate, you will receive whichever therapy you choose, including A or B.

Although this was a heroic effort to try and deliver a trial that came closest to clinical reality, the result was, as one might expect, a trial that remains difficult to interpret. In fact, the principle finding was that the two psychological treatments group were superior to usual care, but were equivalent themselves. Finally, at the end of the trial, all three groups were equally effective. Perhaps this was fortunate since problems could have arisen if at the end of the day one group had been declared clearly superior to the others; the latter finding would, no doubt, have been greeted with accusations of selection bias that would have been difficult to refute.

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Clinical Trials in Psychiatry by Brian S. Everitt, Simon Wessely


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