By Jose Jalife, Mario Delmar, Justus Anumonwo, Omer Berenfeld, Jerome Kalifa
This publication interprets primary wisdom in uncomplicated cardiac electrophysiology from the bench to the bedside. Revised and up-to-date for its moment variation, the textual content deals new assurance of the molecular mechanisms of ion channel habit and its legislation, advanced arrhythmias, and the broadening roles of units and ablation. transparent, effortless motives are illustrated by means of abundant diagrams to make the fabric available to the non-specialist.
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Additional resources for Basic Cardiac Electrophysiology for the Clinician 2nd Edition
Ito, IK and IK1 are outwardly directed (upward deflections) potassium-dependent currents. For illustration purposes, actual magnitudes of currents shown are not scaled. largely permeable to Na+. The concentration of Na+ in the extracellular space (∼140 mM) is significantly larger than in the intracellular space (∼4 mM). 14 shows a computer simulation of the cardiac action potential (top) and the major ionic current components. Clearly, the sodium current (INa) represents a very large, yet rapid transition (note that each current has a 24 Basic Cardiac Electrophysiology for the Clinician different vertical scale).
1 Bioelectricity 31 Although the presence of If in sinus nodal cells has been clearly documented, some authors have argued that the current provided by If in the voltage range of the sinus nodal pacemaker potential is not large enough to solely account for spontaneous pacemaker depolarization. An additional current during phase 4 depolarization may result from the combination of the closure of potassium channels and the activation of calcium currents. , in the positive voltage range). According to this hypothesis, the total membrane current results from the balance of currents moving through these opposing conductances.
The reason is that other conductances with more positive equilibrium potentials may also contribute to the resting potential. For example, in some cells, a small permeability to sodium can be detected at rest. The concentration of sodium in the extracellular space is much larger (∼140 mM) than in the inside (∼10 mM); consequently, the sodium equilibrium potential is more positive than zero. A small conductivity to sodium would therefore tend to bring the resting potential to a less negative level.
Basic Cardiac Electrophysiology for the Clinician 2nd Edition by Jose Jalife, Mario Delmar, Justus Anumonwo, Omer Berenfeld, Jerome Kalifa